|
|
taxa-4(20),11-dien-5alpha-ol + acetyl-CoA <=> taxa-4(20),11-dien-5alpha-yl_acetate + CoA
|
2.3.1.162
taxadien-5alpha-ol O-acetyltransferase
|
–
|
| |
BRENDA:
BR44011
KEGG:
R06307
MetaCyc:
2.3.1.162-RXN
|
|
|
|
L-phenylalanine <=> (S)-beta-phenylalanine
|
5.4.3.10
phenylalanine aminomutase (L-beta-phenylalanine forming)
5.4.3.11
phenylalanine aminomutase (D-beta-phenylalanine forming)
|
–
–
|
| |
BRENDA:
BR50482;
BR52647
KEGG:
R10286;
R10287
MetaCyc:
RXN-13484;
RXN-13649
|
|
|
|
taxa-4(20),11-dien-5alpha-yl_acetate + O2 + reduced_[NADPH-hemoprotein_reductase] <=> 10beta-hydroxytaxa-4(20),11-dien-5alpha-yl_acetate + H2O + oxidized_[NADPH-hemoprotein_reductase]
|
1.14.14.105
taxane 10beta-hydroxylase
|
–
|
| |
MetaCyc:
1.14.13.76-RXN
|
|
|
|
N-debenzoyl-(3''-RS)-taxol + benzoyl-CoA <=> H+ + paclitaxel + CoA
|
2.3.1
|
–
|
| |
KEGG:
R08171
MetaCyc:
RXN-8859
|
|
|
|
taxa-4(20),11-dien-5alpha,13alpha-diol <=> paclitaxel
|
not assigned
|
–
|
| |
MetaCyc:
RXN-8861
|
|
|
|
(S)-beta-phenylalanine + ATP + CoA <=> (3R)-3-amino-3-phenylpropanoyl-CoA + AMP + diphosphate
|
6.2.1
|
–
|
| |
MetaCyc:
RXN-13485
|
|
|
|
geranylgeranyl_diphosphate <=> diphosphate + taxa-4,11-diene
|
4.2.3.17
taxadiene synthase
|
–
|
| |
BRENDA:
BR44341
KEGG:
R06305
MetaCyc:
4.2.3.17-RXN
|
|
|
|
10-deacetylbaccatin_III + acetyl-CoA <=> baccatin_III + CoA
|
2.3.1.167
10-deacetylbaccatin III 10-O-acetyltransferase
|
–
|
| |
BRENDA:
BR44014
KEGG:
R06311
MetaCyc:
2.3.1.167-RXN
|
|
|
|
taxa-4,11-diene + O2 + reduced_[NADPH-hemoprotein_reductase] <=> taxa-4(20),11-dien-5alpha-ol + H2O + oxidized_[NADPH-hemoprotein_reductase]
|
1.14.14.176
taxadiene 5alpha-hydroxylase
|
–
|
| |
MetaCyc:
1.14.99.37-RXN
|
|
|
|
10beta-hydroxytaxa-4(20),11-dien-5alpha-yl_acetate <=> 10-deacetyl-2-debenzoylbaccatin_III
|
not assigned
|
–
|
| |
MetaCyc:
RXN-8865
|
|
|
|
baccatin_III + (3R)-3-amino-3-phenylpropanoyl-CoA <=> N-debenzoyl-(3''-RS)-2''-deoxytaxol + CoA
|
2.3.1
|
–
|
| |
MetaCyc:
RXN-8857
|
|
|
|
N-debenzoyl-(3''-RS)-2''-deoxytaxol + reduced_[NADPH-hemoprotein_reductase] + O2 <=> N-debenzoyl-(3''-RS)-taxol + oxidized_[NADPH-hemoprotein_reductase] + H2O
|
1.14.14
|
–
|
| |
MetaCyc:
RXN-11851
|
|
|
|
10-deacetyl-2-debenzoylbaccatin_III + benzoyl-CoA <=> 10-deacetylbaccatin_III + CoA
|
2.3.1.166
2alpha-hydroxytaxane 2-O-benzoyltransferase
|
–
|
| |
BRENDA:
BR40586
KEGG:
R06310
MetaCyc:
2.3.1.166-RXN
|
|
|
|
10beta-hydroxytaxa-4(20),11-dien-5alpha-yl_acetate + reduced_[NADPH-hemoprotein_reductase] + O2 <=> 10beta,14beta-dihydroxytaxa-4(20),11-dien-5alpha-yl_acetate + oxidized_[NADPH-hemoprotein_reductase] + H2O
|
1.14.13.146
taxoid 14beta-hydroxylase
|
–
|
| |
MetaCyc:
RXN-8855
|
|
|
|
taxa-4(20),11-dien-5alpha-ol + O2 + reduced_[NADPH-hemoprotein_reductase] <=> taxa-4(20),11-dien-5alpha,13alpha-diol + H2O + oxidized_[NADPH-hemoprotein_reductase]
|
1.14.14.106
taxane 13alpha-hydroxylase
|
–
|
| |
MetaCyc:
1.14.13.77-RXN
|
|
