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psilocybin biosynthesis

State Icon Reaction EC-Number Confidence maximal confidence score from EnzymeDetector
4-hydroxy-L-tryptophan + H+ <=> 4-hydroxytryptamine + CO2 4.1.1.105 L-tryptophan decarboxylase

ATP + 4-hydroxytryptamine <=> ADP + 4-hydroxytryptamine_4-phosphate + H+ 2.7.1.222 4-hydroxytryptamine kinase

H+ + L-tryptophan <=> CO2 + tryptamine 4.1.1.105 L-tryptophan decarboxylase
4.1.1.28 aromatic-L-amino-acid decarboxylase
4.1.1.53 phenylalanine decarboxylase



S-adenosyl-L-methionine + 4-hydroxy-N-methyltryptamine_4-phosphate <=> S-adenosyl-L-homocysteine + psilocybin + H+ 2.1.1.345 psilocybin synthase

S-adenosyl-L-methionine + 4-hydroxytryptamine_4-phosphate <=> S-adenosyl-L-homocysteine + 4-hydroxy-N-methyltryptamine_4-phosphate + H+ 2.1.1.345 psilocybin synthase

tryptamine + reduced_[NADPH-hemoprotein_reductase] + O2 <=> 4-hydroxytryptamine + oxidized_[NADPH-hemoprotein_reductase] + H2O 1.14.99.59 tryptamine 4-monooxygenase

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