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phosphopantothenate biosynthesis I

State Icon Reaction EC-Number Confidence maximal confidence score from EnzymeDetector
(R)-pantoate + NADP+ <=> H+ + ketopantoate + NADPH 1.1.1.169 2-dehydropantoate 2-reductase
1.1.1.86 ketol-acid reductoisomerase (NADP+)


beta-Alanine + (R)-pantoate + ATP <=> H+ + pantothenate + diphosphate + AMP 6.3.2.1 pantoate---beta-alanine ligase (AMP-forming)

pantothenate + ATP <=> H+ + (R)-4''-phosphopantothenate + ADP 2.7.1.169 pantoate kinase
2.7.1.33 pantothenate kinase


5,10-methylenetetrahydrofolate + 2-oxoisovalerate + H2O <=> ketopantoate + tetrahydrofolate 2.1.2.11 3-methyl-2-oxobutanoate hydroxymethyltransferase

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