|
|
(R)-mevalonate + ATP <=> (R)-3-phosphomevalonate + ADP + H+
|
2.7.1.185
mevalonate 3-kinase
|
–
|
| |
BRENDA:
BR51126
KEGG:
R10779
MetaCyc:
RXN-15647
|
|
|
|
acetoacetyl-CoA + H2O + acetyl-CoA <=> H+ + CoA + (S)-3-hydroxy-3-methylglutaryl-CoA
|
2.3.3.10
hydroxymethylglutaryl-CoA synthase
|
–
|
| |
BRENDA:
BR44119
KEGG:
R01978
MetaCyc:
HYDROXYMETHYLGLUTARYL-COA-SYNTHASE-RXN
SABIO-RK:
2021
|
|
|
|
isopentenyl_phosphate + ATP <=> isopentenyl_diphosphate + ADP
|
2.7.4.26
isopentenyl phosphate kinase
|
–
|
| |
BRENDA:
BR50003
KEGG:
R10093
MetaCyc:
RXN-10068
|
|
|
|
isopentenyl_diphosphate <=> dimethylallyl_diphosphate
|
5.3.3.2
isopentenyl-diphosphate Delta-isomerase
|
–
|
| |
BRENDA:
BR247
KEGG:
R01123
MetaCyc:
IPPISOM-RXN
SABIO-RK:
1382
|
|
|
|
3,5-diphosphomevalonate + H+ <=> isopentenyl_phosphate + CO2 + phosphate
|
4.1.1.110
bisphosphomevalonate decarboxylase
|
–
|
| |
BRENDA:
BR52424
KEGG:
R10781
MetaCyc:
RXN-15649
|
|
|
|
NADP+ + CoA + (R)-mevalonate <=> H+ + NADPH + (S)-3-hydroxy-3-methylglutaryl-CoA
|
1.1.1.34
hydroxymethylglutaryl-CoA reductase (NADPH)
1.1.1.88
hydroxymethylglutaryl-CoA reductase
1.1.1.B38
|
–
–
–
|
| |
BRENDA:
BR29297;
BR50597;
BS188050;
BS451044
KEGG:
R02082
MetaCyc:
1.1.1.34-RXN
SABIO-RK:
2092
|
|
|
|
(R)-3-phosphomevalonate + ATP <=> 3,5-diphosphomevalonate + ADP + H+
|
2.7.1.186
mevalonate-3-phosphate 5-kinase
|
–
|
| |
BRENDA:
BR51127;
BS427356
KEGG:
R10780
MetaCyc:
RXN-15648
|
|
|
|
acetyl-CoA <=> acetoacetyl-CoA + CoA
|
1.1.1.34
hydroxymethylglutaryl-CoA reductase (NADPH)
2.3.1.155
acetyl-CoA C-myristoyltransferase
2.3.1.16
acetyl-CoA C-acyltransferase
2.3.1.38
[acyl-carrier-protein] S-acetyltransferase
2.3.1.9
acetyl-CoA C-acetyltransferase
|
–
–
–
–
–
|
| |
BRENDA:
BR44092
KEGG:
R00238
MetaCyc:
ACETYL-COA-ACETYLTRANSFER-RXN
SABIO-RK:
531
|
|
