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hyperforin and adhyperforin biosynthesis

State Icon Reaction EC-Number Confidence maximal confidence score from EnzymeDetector
dimethylallyl_diphosphate + 4-prenylphlorisobutyrophenone <=> diphosphate + deoxycohumulone 2.5.1.137 2-acyl-4-prenylphloroglucinol 6-prenyltransferase

dimethylallyl_diphosphate + 3-methyl-1-[2,4,6-trihydroxy-3-(3-methylbut-2-en-1-yl)phenyl]propan-1-one <=> diphosphate + deoxyhumulone 2.5.1.137 2-acyl-4-prenylphloroglucinol 6-prenyltransferase

dimethylallyl_diphosphate + phloroisovalerophenone <=> diphosphate + 3-methyl-1-[2,4,6-trihydroxy-3-(3-methylbut-2-en-1-yl)phenyl]propan-1-one + H+ 2.5.1.136 2-acylphloroglucinol 4-prenyltransferase

isobutyryl-CoA + malonyl-CoA + H+ <=> phloroisobutyrophenone + CO2 + CoA 2.3.1.156 phloroisovalerophenone synthase
2.3.1.220 2,4,6-trihydroxybenzophenone synthase


deoxycohumulone + dimethylallyl_diphosphate + geranyl_diphosphate + H+ <=> hyperforin + diphosphate not assigned

deoxyhumulone + geranyl_diphosphate + dimethylallyl_diphosphate + H+ <=> adhyperforin + diphosphate not assigned

dimethylallyl_diphosphate + phloroisobutyrophenone <=> diphosphate + 4-prenylphlorisobutyrophenone + H+ 2.5.1.136 2-acylphloroglucinol 4-prenyltransferase

isovaleryl-CoA + malonyl-CoA + H+ <=> phloroisovalerophenone + CO2 + CoA 2.3.1.156 phloroisovalerophenone synthase
2.3.1.220 2,4,6-trihydroxybenzophenone synthase


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