Copied!

Pathway Search



holomycin biosynthesis

State Icon Reaction EC-Number Confidence maximal confidence score from EnzymeDetector
(2E)-2-[(2E)-2-azanidyl-3-sulfanylprop-2-enamido]-3-[HlmE_non-ribosomal_peptide_synthetase] <=> 4-amino-2-(methanethioyl)-5-oxo-3-sulfanylpyrrolidine-2-carboxyl-[HlmE_non-ribosomal_peptide_synthetase] not assigned

(5E)-3-imino-4-sulfanyl-5-(sulfanylmethylidene)pyrrolidin-2-one <=> dithioholothin not assigned

(2E)-2-amino-3-sulfanylprop-2-enoyl-[HlmE_non-ribosomal_peptide_synthetase] + L-cysteine + acceptor + ATP <=> (2E)-2-[(2E)-2-azanidyl-3-sulfanylprop-2-enamido]-3-[HlmE_non-ribosomal_peptide_synthetase] + reduced_acceptor + AMP + diphosphate + H+ 6.3.2

dithioholothin + O2 <=> holothin + H2O2 1.8.3.M1

4-amino-2-(methanethioyl)-5-oxo-3-sulfanylpyrrolidine-2-carboxyl-[HlmE_non-ribosomal_peptide_synthetase] + H2O <=> 4-amino-2-(methanethioyl)-5-oxo-3-sulfanylpyrrolidine-2-carboxylate + HlmE_non-ribosomal_peptide_synthetase + H+ 3.1.2

L-cysteinyl-[HlmE_non-ribosomal_peptide_synthetase] + acceptor <=> (2E)-2-amino-3-sulfanylprop-2-enoyl-[HlmE_non-ribosomal_peptide_synthetase] + reduced_acceptor not assigned

acetyl-CoA + dithioholothin <=> dithioholomycin + CoA 2.3.1

acetyl-CoA + holothin <=> holomycin + CoA 2.3.1

4-amino-2-(methanethioyl)-5-oxo-3-sulfanylpyrrolidine-2-carboxylate + H+ <=> (5E)-3-amino-4-sulfanyl-5-(sulfanylmethylidene)pyrrolidin-2-one + CO2 4.1.1

HlmE_non-ribosomal_peptide_synthetase + L-cysteine + ATP <=> L-cysteinyl-[HlmE_non-ribosomal_peptide_synthetase] + AMP + diphosphate 6.3.2

dithioholomycin + O2 <=> holomycin + H2O2 1.8.3.M1

(5E)-3-amino-4-sulfanyl-5-(sulfanylmethylidene)pyrrolidin-2-one + acceptor <=> (5E)-3-imino-4-sulfanyl-5-(sulfanylmethylidene)pyrrolidin-2-one + H+ + reduced_acceptor 1.4.99

Visualization of the pathway