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griseofulvin biosynthesis

State Icon Reaction EC-Number Confidence maximal confidence score from EnzymeDetector
S-adenosyl-L-methionine + griseophenone_D <=> griseophenone_C + S-adenosyl-L-homocysteine + H+ 2.1.1

dehydrogriseofulvin + NADPH + H+ <=> griseofulvin + NADP+ 1.3.1

S-adenosyl-L-methionine + 2-(2,4-dihydroxy-6-methylbenzoyl)benzene-1,3,5-triol <=> griseophenone_D + S-adenosyl-L-homocysteine + H+ 2.1.1

S-adenosyl-L-methionine + desmethyl-dehydro-griseofulvin <=> dehydrogriseofulvin + S-adenosyl-L-homocysteine + H+ 2.1.1

acetyl-CoA + malonyl-CoA + [acyl-carrier_protein] + H+ <=> 1-(2,4-dihydroxy-6-methylphenyl)octane-1,3,5,7-tetrone-[acp] + CoA + CO2 + H2O 2.3.1

griseophenone_B + NADPH + H+ + O2 <=> desmethyl-dehydro-griseofulvin + NADP+ + H2O 1.14.19

2-(2,4-dihydroxy-6-methylbenzoyl)benzene-1,3,5-triol <=> norlichexanthone + H2O not assigned

1-(2,4-dihydroxy-6-methylphenyl)octane-1,3,5,7-tetrone-[acp] <=> 2-(2,4-dihydroxy-6-methylbenzoyl)benzene-1,3,5-triol + [acyl-carrier_protein] 2.3.1

griseophenone_C + Cl- + FADH2 + O2 <=> griseophenone_B + FAD + H2O 1.14.19

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