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colupulone and cohumulone biosynthesis

State Icon Reaction EC-Number Confidence maximal confidence score from EnzymeDetector
dimethylallyl_diphosphate + 4-prenylphlorisobutyrophenone <=> diphosphate + deoxycohumulone 2.5.1.137 2-acyl-4-prenylphloroglucinol 6-prenyltransferase

ATP + Isobutyrate + CoA <=> diphosphate + AMP + isobutyryl-CoA 6.2.1.1 acetate---CoA ligase
6.2.1.2 medium-chain acyl-CoA ligase
6.2.1.44 3-(methylthio)propionyl---CoA ligase



isobutyryl-CoA + malonyl-CoA + H+ <=> phloroisobutyrophenone + CO2 + CoA 2.3.1.156 phloroisovalerophenone synthase
2.3.1.220 2,4,6-trihydroxybenzophenone synthase


dimethylallyl_diphosphate + deoxycohumulone <=> diphosphate + colupulone 2.5.1.137 2-acyl-4-prenylphloroglucinol 6-prenyltransferase

dimethylallyl_diphosphate + phloroisobutyrophenone <=> diphosphate + 4-prenylphlorisobutyrophenone + H+ 2.5.1.136 2-acylphloroglucinol 4-prenyltransferase

deoxycohumulone + O2 + reduced_acceptor <=> cohumulone + H2O + acceptor 1.14.99.M4

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