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chloramphenicol biosynthesis

State Icon Reaction EC-Number Confidence maximal confidence score from EnzymeDetector
4-amino-L-phenylalanyl-[CmlP-peptidyl-carrier-protein] + O2 + reduced_acceptor <=> 2-(4-aminophenyl)-L-seryl-[CmlP-peptidyl-carrier-protein] + H2O + acceptor 1.14.99.65 4-amino-L-phenylalanyl-[CmlP-peptidyl-carrier-protein] 3-hydroxylase

4-amino-4-deoxyprephenate + NAD+ <=> 3-(4-Aminophenyl)-2-oxopropanoate + CO2 + NADH + H+ 1.3.1.121 4-amino-4-deoxyprephenate dehydrogenase

alpha-N-dichloroacetyl-p-aminophenylserinol + reduced_acceptor + O2 <=> Chloramphenicol + acceptor + H2O 1.14.99.af

4-amino-L-phenylalanine + 2-oxoglutarate <=> 3-(4-Aminophenyl)-2-oxopropanoate + L-glutamate 2.6.1
2.6.1.57 aromatic-amino-acid transaminase


dichloroacetyl-[acp] + (1R,2R)-2-amino-1-(4-aminophenyl)propane-1,3-diol <=> alpha-N-dichloroacetyl-p-aminophenylserinol + H+ + soluble_holo-[acyl-carrier_protein] 2.3.1

4-amino-4-deoxychorismate <=> 4-amino-4-deoxyprephenate 5.4.99.67 4-amino-4-deoxychorismate mutase

2-(4-aminophenyl)-L-seryl-[CmlP-peptidyl-carrier-protein] + NADPH + H+ <=> (1R,2R)-2-amino-1-(4-aminophenyl)propane-1,3-diol + holo-[CmlP-peptidyl-carrier_protein] + NADP+ not assigned

chorismate + L-glutamine <=> 4-amino-4-deoxychorismate + L-glutamate 2.6.1.85 aminodeoxychorismate synthase

holo-[CmlP-peptidyl-carrier_protein] + 4-amino-L-phenylalanine + ATP <=> 4-amino-L-phenylalanyl-[CmlP-peptidyl-carrier-protein] + AMP + diphosphate 6.2.1

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