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backdoor pathway of androgen biosynthesis

State Icon Reaction EC-Number Confidence maximal confidence score from EnzymeDetector
5-Pregnene-3,20-dione <=> progesterone 5.3.3.1 steroid Delta-isomerase

pregnenolone + NAD+ <=> 5-Pregnene-3,20-dione + NADH + H+ 1.1.1.145 3beta-hydroxy-Delta5-steroid dehydrogenase
1.1.1.51 3(or 17)beta-hydroxysteroid dehydrogenase


pregnenolone + reduced_[NADPH-hemoprotein_reductase] + O2 <=> 17alpha-hydroxypregnenolone + oxidized_[NADPH-hemoprotein_reductase] + H2O 1.14.14.19 steroid 17alpha-monooxygenase

5alpha-Androstane-3beta,17beta-diol + NADP+ <=> 5alpha-dihydrotestosterone + NADPH + H+ 1.1.1.145 3beta-hydroxy-Delta5-steroid dehydrogenase
1.1.1.184 carbonyl reductase (NADPH)
1.1.1.210 3beta(or 20alpha)-hydroxysteroid dehydrogenase
1.1.1.270 3beta-hydroxysteroid 3-dehydrogenase
1.1.1.50 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific)
1.1.1.51 3(or 17)beta-hydroxysteroid dehydrogenase
1.1.1.62 17beta-estradiol 17-dehydrogenase







progesterone + O2 + reduced_[NADPH-hemoprotein_reductase] <=> 17alpha-hydroxyprogesterone + oxidized_[NADPH-hemoprotein_reductase] + H2O 1.14.14.19 steroid 17alpha-monooxygenase

pregn-5-ene-3,20-dione-17-ol <=> 17alpha-hydroxyprogesterone 5.3.3.1 steroid Delta-isomerase

17alpha-hydroxypregnenolone + NAD+ <=> NADH + H+ + pregn-5-ene-3,20-dione-17-ol 1.1.1.145 3beta-hydroxy-Delta5-steroid dehydrogenase

Visualization of the pathway