Pathway Search

TCA cycle III (animals)

State Icon Reaction EC-Number Confidence maximal confidence score from EnzymeDetector
cis-aconitate + H2O <=> isocitrate aconitate hydratase

acetyl-CoA + H2O + oxaloacetate <=> citrate + CoA + H+ citrate (Si)-synthase homocitrate synthase citrate synthase (unknown stereospecificity) citrate (Re)-synthase

(S)-malate <=> fumarate + H2O fumarate hydratase (S)-2-methylmalate dehydratase

succinate + GTP + CoA <=> succinyl-CoA + GDP + phosphate succinate---CoA ligase (GDP-forming)

succinate + CoA + ATP <=> succinyl-CoA + ADP + phosphate acetate---CoA ligase (ADP-forming) succinate---CoA ligase (GDP-forming) succinate---CoA ligase (ADP-forming)

ubiquinone + succinate <=> ubiquinol + fumarate succinate dehydrogenase fumarate reductase (quinol)

(S)-malate + NAD+ <=> oxaloacetate + NADH + H+ D-lactate dehydrogenase malate dehydrogenase [NAD(P)+] L-2-hydroxycarboxylate dehydrogenase (NAD+) malate dehydrogenase L-2-hydroxycarboxylate dehydrogenase [NAD(P)+] malate dehydrogenase (oxaloacetate-decarboxylating) hydroxypyruvate reductase malate dehydrogenase (NADP+) 3-isopropylmalate dehydrogenase phosphoglycerate dehydrogenase diiodophenylpyruvate reductase

citrate <=> cis-aconitate + H2O 2-methylcitrate dehydratase (2-methyl-trans-aconitate forming) aconitate hydratase

2-oxoglutarate + CoA + NAD+ <=> succinyl-CoA + CO2 + NADH 1.2.1.ak oxoglutarate dehydrogenase (succinyl-transferring) 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) dihydrolipoyl dehydrogenase dihydrolipoyllysine-residue succinyltransferase

isocitrate + NAD+ <=> 2-oxoglutarate + CO2 + NADH isocitrate---homoisocitrate dehydrogenase isocitrate dehydrogenase (NAD+) isocitrate dehydrogenase (NADP+) homoisocitrate dehydrogenase

Visualization of the pathway