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TCA cycle II (plants and fungi)

State Icon Reaction EC-Number Confidence maximal confidence score from EnzymeDetector
cis-aconitate + H2O <=> isocitrate 4.2.1.3 aconitate hydratase

acetyl-CoA + H2O + oxaloacetate <=> citrate + CoA + H+ 2.3.3.1 citrate (Si)-synthase
2.3.3.14 homocitrate synthase
2.3.3.16 citrate synthase (unknown stereospecificity)
2.3.3.3 citrate (Re)-synthase




(S)-malate <=> fumarate + H2O 4.2.1.2 fumarate hydratase
4.2.1.34 (S)-2-methylmalate dehydratase


succinate + CoA + ATP <=> succinyl-CoA + ADP + phosphate 6.2.1.13 acetate---CoA ligase (ADP-forming)
6.2.1.4 succinate---CoA ligase (GDP-forming)
6.2.1.5 succinate---CoA ligase (ADP-forming)



(S)-malate + NAD+ <=> oxaloacetate + NADH + H+ 1.1.1.28 D-lactate dehydrogenase
1.1.1.299 malate dehydrogenase [NAD(P)+]
1.1.1.337 L-2-hydroxycarboxylate dehydrogenase (NAD+)
1.1.1.37 malate dehydrogenase
1.1.1.375 L-2-hydroxycarboxylate dehydrogenase [NAD(P)+]
1.1.1.38 malate dehydrogenase (oxaloacetate-decarboxylating)
1.1.1.81 hydroxypyruvate reductase
1.1.1.82 malate dehydrogenase (NADP+)
1.1.1.85 3-isopropylmalate dehydrogenase
1.1.1.95 phosphoglycerate dehydrogenase
1.1.1.96 diiodophenylpyruvate reductase











citrate <=> cis-aconitate + H2O 4.2.1.117 2-methylcitrate dehydratase (2-methyl-trans-aconitate forming)
4.2.1.3 aconitate hydratase


2-oxoglutarate + CoA + NAD+ <=> succinyl-CoA + CO2 + NADH 1.2.1.ak
1.2.4.2 oxoglutarate dehydrogenase (succinyl-transferring)
1.2.4.4 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)
1.8.1.4 dihydrolipoyl dehydrogenase
2.3.1.61 dihydrolipoyllysine-residue succinyltransferase





electron-transfer_quinone + succinate <=> electron-transfer_quinol + fumarate 1.3.5.1 succinate dehydrogenase

isocitrate + NAD+ <=> 2-oxoglutarate + CO2 + NADH 1.1.1.286 isocitrate---homoisocitrate dehydrogenase
1.1.1.41 isocitrate dehydrogenase (NAD+)
1.1.1.42 isocitrate dehydrogenase (NADP+)
1.1.1.87 homoisocitrate dehydrogenase




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