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L-lysine degradation II (L-pipecolate pathway)

State Icon Reaction EC-Number Confidence maximal confidence score from EnzymeDetector
H+ + DELTA1-piperideine-2-carboxylate + H2O <=> 6-Amino-2-oxohexanoate not assigned

2-oxoadipate + NAD+ + CoA <=> CO2 + NADH + glutaryl-CoA 1.2.1.ak
1.2.4.2 oxoglutarate dehydrogenase (succinyl-transferring)
1.8.1.4 dihydrolipoyl dehydrogenase
2.3.1.61 dihydrolipoyllysine-residue succinyltransferase




L-2-aminoadipate + 2-oxoglutarate <=> L-glutamate + 2-oxoadipate 2.6.1.39 2-aminoadipate transaminase
2.6.1.7 kynurenine---oxoglutarate transaminase


DELTA1-piperidine_6-carboxylate + NADP+ + H2O <=> L-2-aminoadipate + NADPH + H+ 1.2.1.31 L-aminoadipate-semialdehyde dehydrogenase

L-lysine + H2O + O2 <=> 6-Amino-2-oxohexanoate + NH3 + H2O2 1.13.12.2 lysine 2-monooxygenase
1.4.3.14 L-lysine oxidase
1.4.3.2 L-amino-acid oxidase
1.4.3.25 L-arginine oxidase




L-lysine + 2-oxoglutarate <=> 6-Amino-2-oxohexanoate + L-glutamate 2.6.1
2.6.1.42 branched-chain-amino-acid transaminase


L-pipecolic_acid + NADP+ <=> DELTA1-piperideine-2-carboxylate + NADPH + H+ 1.5.1.1 1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase [NAD(P)H]
1.5.1.21 1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase (NADPH)
1.5.1.25 thiomorpholine-carboxylate dehydrogenase
1.5.1.49 1-pyrroline-2-carboxylate reductase [NAD(P)H]




L-pipecolic_acid + NADP+ <=> DELTA1-piperidine_6-carboxylate + NADPH + H+ 1.5.1
1.5.1.2 pyrroline-5-carboxylate reductase


L-pipecolic_acid + O2 <=> H+ + DELTA1-piperidine_6-carboxylate + H2O2 1.5.3.7 L-pipecolate oxidase

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