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6-methylpretetramide biosynthesis

State Icon Reaction EC-Number Confidence maximal confidence score from EnzymeDetector
C9-reduced_nonaketamide-[OxyC_acyl-carrier_protein] <=> nonaketamide_monocyclic_intermediate-[OxyC_acyl-carrier_protein] + H2O 4.2.1.M9

Malonamoyl-CoA + OxyC_acyl-carrier_protein <=> malonamoyl-[OxyC_acyl-carrier_protein] + CoA 2.3.1.M29

nonaketamide_tricyclic_intermediate-[OxyC_acyl-carrier_protein] <=> Pretetramid + OxyC_acyl-carrier_protein + H+ 5.5.1

malonamoyl-[OxyC_acyl-carrier_protein] + malonyl-CoA + H+ <=> 18-carbamoyl-3,5,7,9,11,13,15,17-octaoxooctadecanoyl-[OxyC_acyl-carrier_protein] + CO2 + CoA 2.3.1.260 tetracycline polyketide synthase

nonaketamide_monocyclic_intermediate-[OxyC_acyl-carrier_protein] <=> nonaketamide_tricyclic_intermediate-[OxyC_acyl-carrier_protein] + H2O 4.2.1.M10

S-adenosyl-L-methionine + Pretetramid <=> S-adenosyl-L-homocysteine + 6-methylpretetramide + H+ 2.1.1
2.1.1.M31


malonyl-CoA + L-glutamine + ATP + H2O <=> Malonamoyl-CoA + L-glutamate + AMP + diphosphate + H+ 6.3.5
6.3.5.M2


C9-reduced_nonaketamide-[OxyC_acyl-carrier_protein] + NADP+ <=> 18-carbamoyl-3,5,7,9,11,13,15,17-octaoxooctadecanoyl-[OxyC_acyl-carrier_protein] + NADPH + H+ 1.1.1.M31

Visualization of the pathway