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Welcome to the homepage of metano. If you use the software for your own published work, we kindly ask that you cite our recent publication.

Table of Contents
What is metano?
Download metano
Quick reference
Publications
Contact information
License information
What is metano?
metano is an open-source software toolbox for analyzing the capabilities of metabolic networks and for assisting in metabolic reconstruction. The software is written in Python and is designed to be easy to use and run reasonably fast. metano contains efficient implementations of the established computational methods flux balance analysis (FBA), minimization of metabolic adjustment (MOMA), and flux variability analysis (FVA), as well as a script for automatically analyzing all specified single- or multi-gene knockouts using MOMA or FBA, respectively. In addition, metano provides several newly developed methods, including the automated plausibility checking of metabolic models and methods for the metabolite-centric analysis of flux distributions (see our publication).

All methods implemented in metano are available both as Python functions and as stand-alone command line scripts, which take lists of reactions in plain ASCII format as input. metano is designed to run in any Linux environment. Algorithms with a long running time have been parallelized using MPI, which allows their execution on computer clusters.

As all tools are available as stand-alone scripts that require no adjustment of numerical parameters, metano is very easy to use by modelers without any programming experience.

Features and release notes
Download metano
Click here to download the current release, metano v1.0.

The previous release v0.9.0 (July 2012) is available from here.

Installation instructions
Quick reference
A quick reference for metano can be found here.
Publications
Riemer SA, Rex R, Schomburg D. A metabolite-centric view on flux distributions in genome-scale metabolic models. BMC Syst Biol, 7:33 (2013). Free full text
Contact information
If you have any questions regarding metano or this website, please contact

Alexander Riemer
Technische Universität Carolo-Wilhelmina zu Braunschweig
Department of Bioinformatics and Biochemistry
Langer Kamp 19b
38106 Braunschweig, Germany
E-Mail: My e-mail address
Phone: +49 531 391-8306

The website of our department can be found here.
License information
metano is free software: you can redistribute it and/or modify it under the terms of the GNU General Public License as published by the Free Software Foundation, either version 3 of the License, or (at your option) any later version.

metano is distributed in the hope that it will be useful, but WITHOUT ANY WARRANTY; without even the implied warranty of MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE. See the GNU General Public License for more details.

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